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Old 29th September 2016, 04:11 PM
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Default Cd4 SMU

Hello Buddy!!! I am here as I want to know the goals of the Cd4 of Southern Methodist University so will you please tell me the Goals??
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Old 29th September 2016, 04:30 PM
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Default Re: Cd4 SMU

Hey!!! The Center for Drug Discovery, Design and Delivery (CD4) at Southern Methodist University's Dedman College of the Humanities and Sciences is a novel multi-disciplinary focus for scientific research targeting medically important problems in human health.


Center Goals of CD4 are


-Synergistic interaction to increase research and grantsmanship potential for faculty and students through the cooperation and sharing of member laboratory skills, knowledge and capabilities.

-Increase funding through funding mechanisms that are available to Centers but are not available to individual investigators or even teams of investigators.

-Increase visibility for Dedman College to the external community.

-Increase recruitment prospects for the pre-health professional and natural sciences and engineering students.

-Increase revenue through positive recruitment balances and external Certificate programs tuitions.

-More efficient utilization of existing faculty and physical plant assets in a defined translational environment.

-Future potential discoveries that may represent significant revenue sources for the University (patent and licensing royalties).

-Educational opportunities that will positively impact undergraduate and graduate student recruitment to SMU as well as being attractive to area professionals.


CD4’s mission is to potentiate the development of new therapeutics, their delivery methods as well as the translation of these new therapeutics to clinical studies.

Training new generations of biomedical researchers in state-of-the-art techniques completes the overall mission of the center.


Facilities

I. Department of Chemistry Facilities

- 400 MHz Bruker Avance and 500 MHz JEOL ECA multinuclear (1H, 13C, 31P, 29Si, 19F) NMR spectrometers (used for characterization of products)
- Two Nicolet FT-IR spectrometers (used for characterization of products)
- Perkin-Elmer and Ocean Optics UV/Vis spectrometers (used to measure optical absorptions of products)
- Hitachi F-7000 fluorescence spectrophotometer (used to measure excitation and emission spectra of fluorescent materials)
- Agilent Technologies 6850 Series II GC-MS (used for characterization of liquid mixtures of products)
- Thermo-Finnigan LCQ Advantage LC-MS (used for the separation and molecular ion analysis of product mixtures)
- Bruker APEX X-Ray diFfractometer system with CCD area detector (used to determine crystal structures of any crystalline products)
- TA Instruments Model 2960 Thermogravimetric Analyzer (TGA) and Model 2010 Differential Scanning Calorimeter (DSC) equipped with low temperature cooling accessory (used to measure weight loss and thermal fluctuations over wide temperature ranges, especially for polymers)
- CE Elantech Thermo-Finnigan Flash 1112 CHN elemental analyzer (for combustion elemental analysis)
- Cyclic voltammetry equipment for determination of redox potentials, related to studies of polymer degradation in reducing environments

II. Computational chemistry labs

Teaching: Newly renovated computer lab with 10 student IMacs + 1 instructor IMac.
Research: The computational and theoretical chemistry group (CATCO, http://smu.edu/catco/) is equipped with a new symmetric multiprocessing and shared memory computer cluster. The resources of individual nodes are combined via an aggregated virtual machine that allows a single operating system instance to run above the discrete machines comprising the cluster.

Total:
Nodes 16
CPU's 32
Cores 128
Simultaneous Threads 256
Memory 768 GB
Hard Drive Capacity 16 TB

Per Node:
CPU's 2
Cores 8
Simultaneous Threads 16
Memory 48 GB
Hard Drive Capacity 1 TB
Network Interconnects 32 Gbit/s


III. Synthetic organic labs

- CEM Microwave reactor
- CEM Cool Mate
- Drybox (for work with air-sensitive reaction intermediates)
- Centrifuges
- UV/Vis spectrometer for characterization and kinetic measurements (e.g., enzyme kinetics)
The synthetic labs are have all the necessary glassware and common lab equipment needed for synthesis of complex organic molecules (from milligram to multi-gram quantities) and for purification.

IV. Polymer synthetic labs
- Microwave reactor used for synthesis of polymeric materials
- Gas chromatograph for following reaction progress
- Organic and aqueous gel permeation chromatographs (GPC) for analysis of molecular weight and molecular weight distribution of polymers with refractive index detector or with additional triple detection. The GPCs allow for studying polymer degradation.
- UV/Vis/NIR spectrometer with precise temperature control for studying kinetics of reactions, including polymer degradation and drug release. Additional UV/Vis spectrometer with temperature control.
- ATP-FTIR spectrophotometer with in situ ATR capabilities.
- Dynamic light scattering for measuring particle or polymeric aggregate sizes useful for studying degradation of polymers.
- Optical microscope equipped with a video camera useful for observation of larger polymeric particles (> 300 nm), their degradation and release of incorporated compounds.
- Equipment for freeze-drying used for polymer purification.
In addition, the polymer synthesis labs are equipped with vacuum lines, freeze-drying equipment, and other more conventional equipment needed for the synthesis and purification of polymers and polymer-drug or polymer-targeting molecule conjugates.

V . Department of Biology
- PTI Quantamaster 40 Spectrofluorometer
- plate-reading fluorimeter
- gel-documentation system
- laminar flow hoods
- CO2 incubators
- Shaker incubators
- Incubators
- Bruker ESR spectrophotometer
- High speed centrifuges
- Ultra centrifuges
- UV spectrophotometers
- UV plate readers
- Beckman Gold HPLC with diode array detector
- Beckman DU800 UV/VIS spectrophotometer
- Nikon TE2000-E/C1 confocal-imaging system with two He-Ne lasers and 488nm Argon laser
- Nikon upright fluorescence-microscope with DIC optics
- Becton Dickinson FACSCaliber flow-cytometer
- Corbett RG-3000 real-time qPCR instrument
- Microm HM505E cryomicrotome,
- shared-use tissue/cell culture areas with humidified 37 degree CO2 incubators
- Class II biological safety cabinets,
- controlled temperature 4 degree rooms,
- -80 degree freezers with CO2 backup systems,
- darkrooms for imaging and quantification of nucleic acids and proteins,
- automatic autoclaves
- dishwashers
- dry ovens
- media preparation areas
- Agilent 7820 GC-MS for metabolic profiling

Contact Details:
Dedman College of Humanities & Sciences
PO Box 750235
Dallas, Texas
75275-0235
214-768-2440
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