Model Test Papers For Gpat

I have come to obtain GPAT Model Test Papers For preparation of this exam so will you plz provide me same or tell me from where I can do download it ??

[Arvind Kumar]

As you want here I am giving below GPAT Model Test Papers on your demand:

Q. 1 Which of the following phenothiazine neuroleptic is a piperidine derivative ?
Thioridazine
Trifluperazine
Perphenazine
Promazine
Q. 2. Neuroleptics mediated parkinsonism is alleviated by
Antimuscarinics
Amantadine
Levodopa
Selgiline
Q. 3 Which of the following drugs is both α and β blocker ?
Phentolamine
Phenoxybenzamine
Labetalol
Indoramin
Q. 4 Digitalis toxicity is aggravated by
Hypokalemia
Hyponatremia
Hypocalcemia
Hypomagnesimia
Q. 5. Preferred antihypertensive drug during pregnancy is *
Propranolol
Hydralazine
Hydrochlorthiazide
Sodium nitropruside
Q. 6 All of the following are first line antitubercular drugs except *
Isoniazid
Rifampicin
Kanamycin
Ethambutol
Q. 7 Combination of drug which is effective in the treatment of angina-pectoris is
Atenolol, Isoproterenol, diltiazem
Isosorbide, nifedipine, propranolol
Nitroglycerin, Isosorbide, atenolol
None of the above
Q. 8 Isoxuprine is used to treat
Asthma
Severe Hypotension
Nasal congestion
Premature labor
Q. 9 A young woman complains of severe abdominal pain at the time of menstruation. Carefulevaluation indicates the presence of significant endometrial deposits on the pelvicperitonium.The most rational therapy for this patient would be *
Flutamide
Danazol
Mestranol
Estradiol
Q. 10 The primary standard used to standardize acetous perchloric acid is
Benzoic acid
Potassium hydrogen phthalate
Oxalic acid
Sodium carbonate
Q. 11 Which of the following is used to damask zinc from the zinc-cyanide complex ?
Tiron
Potassium iodide
Chloral hydrate
Triethanolamine
Q. 12 The IR detector which consists of a small metal cylinder closed by a blackened metal plateon one end and a flexible metalized diaphragm on the other is
Bolometer
Thermistor
Golay cell
Pyroelectric detectors
Q. 13 The Henderson’s equation states that
pH = pKa + log [[salt] /[acid]]
pH = pKa – log [salt] /[acid]
pH = pKa – log [acid] /[salt]
pH = pKa + log [[acid] /[salt]]
Q. 14. The standard redox potential of MnO4– / Mn+2 systems is
+ 1.52 V
– 0.51 V
+ 0.77 V
– 0.06 V
Q. 15 Which of the following is not true for Eddy diffusion in chromatography ?
it is related to particle size, geometry and tightness of packing of the stationaryphase.
It results in the broadening of the eluted band
It is independent of flow rate
It results from the tendency of the molecules to migrate from the concentrated centrepart of the band towards more dilute regions on either side.
Q. 16 Which of the following transitions require the lowest energy for excitation in the UV region ?
π → π*
σ → σ*
n → π*
n → σ*
Q. 17 For the measurement of higher conductivity the cell consists of
Small electrodes separated by long distance
Small electrodes separated by short distance
Large electrode separated by long distance
Large electrode separated by short distance
Q. 18 The precipitating agent used to precipitate calcium as calcium oxalate in gravimetry is
Oxalic acid
Sodium oxalate
Ammonium oxalate
Cupferron
Q. 19 Assay of Sulphamethoxazole is done by
Acid base titration
Non-aqueous titration
Redox titration
Diazotisation titration
Q. 20 The reagent gas used for chemical ionization in mass spectrometry is
Methane
Ethane
Propane
Hexane
Q. 21 The indicator electrode used in polarography is
Glass electrode
Rotating platinum electrode
Dropping mercury electrode
Antimony-Antimony oxide electrode
Q. 22 The reduction of fluorescence intensity due to the complex formation of riboflavin by Caffeine is an example of *
Physical quenching
Static quenching
Colloidal quenching
Chemical quenching
Q. 23. In a double focusing mass spectrometer
Two beams are used separately
Two samples can be analyzed
Sample and reference beams are present
Electrostatic and magnetic analyzers are present
Q. 24 The sample cells used in IR spectroscopy are made up of
Glass
Quartz
Alkyl halides
Any material
Q. 25 Fischer’s ‘lock & key’ model of the enzyme action implies that
The active site is complementary in shape to that of the substance only afterinteraction
The active site is complementary in shape to that of the substance.
Substrates change confirmation prior to active site interaction.
The active site is flexible & adjusts to substrate.
Q. 26 In the citric acid cycle, citric acid is formed by a combination of acetate & a molecule of
Oxaloacetate
Glucose
Pyruvic acid
Lactic acid
Q. 27 The enzymes required for the β-oxidation are present in
Mitochondria
Nucleus
Endoplasmic reticulum
Cytoplasm
Q. 28 The process which contributes to purine nucleotide biosynthesis is
ribosylation of purine synthesis from basic intermediates
synthesis from basic intermediates
synthesis from amphibolic intermediates
synthesis from acidic intermediates
Q. 29 In the Eukaryotic cells, transcription complex contains *
Template strand of DNA
RNA-polymerase
Sigma factors
All of the above
Q. 30 Transcription bubble contains
RNA polymerase
DNA
Nascent-RNA
All of the above
Q. 31 The Central Pharmacy Council comprises the following members :
Six members from the teachers of pharmacy, the director-general of health services& the ex-officio, Drugs Controller, India.
Two members from the teachers of pharmacy, one member elected by the MedicalCouncil of India & the Director of Central Drug Laboratory.
Two members from practicing pharmacists, six members elected by the MedicalCouncil of India & five representatives from the AICTE
Six members to represent each State Council who shall be a registered pharmacist,the Deputy Director CDL & one member elected by the Medical Council of India.
Q. 32 A drug shall be deemed to be adulterated if
it is manufactured and stored under hygienic conditions
it does not contain harmful or toxic substances
it has not been mixed with any substance to reduce its quality
it bears a colour other than one which is prescribed
Q. 33 Schedule T of Drugs & Cosmetics rules, 1945 deals with *
GMP for Ayurveda, Siddha & Unani medicines
Standards for Cosmetics
Requirements of factory premises for manufacture of medical devices
Biological & Special products
Q. 34. Form 28 is
Application for grant/renewal of license to manufacture blood products for sale ordistribution
Application for grant/renewal of a loan license to manufacture for sale or fordistribution of drugs specified in schedules C1 & C2
Certificate of renewal of license for manufacture of blood products
For obtaining license to manufacture for sale or for distribution of drugs specified inSchedules C & C1
Q. 35. Insulin injection comes under Schedule
S
P
G
A
Q. 36. Gram positive bacteria
Retain crystal violet & hence appear deep violet in colour
Lose crystal violet & hence appear transparent
Lose crystal violet & are counterstained by safranin & hence appear red in colour
Lose crystal violet & are counterstained by safranin & hence appear green in colour
Q. 37 Fractional sterilization method involves
Heating the material at 121 °C & 15 lb/in2 pressure
Heating the material at 160 °C for 2 hours
Heating the material to 100 °C on 3 consecutive days with incubation periods inbetween
Heating the material to 105 °C for 1 hour
Q. 38 In the microbiological assay of Bacitracin IP, the test organism used is
Staphylococcus aures
Staphylococcus epidermis
Micrococcus luteus
Bacillus pumilus
Q. 39 Hybridoma is
The fusion of a cancer cell & an antibody making cell
The fusion of a cancer cell & an antigen
The fusion of a non-cancerous cell & an antibody making cell
The fusion of a non-cancerous cell & an antigen
Q. 40 The oral Sabin vaccine contains
Killed poliomyelitis virus
Live virus
Killed cells of Salmonella typhi
Chemically treated Corynebacterium diphtheria
Q. 41 Log P value is a measure of
Ionization potential of a molecule
Solubility characteristics of the entire molecule
Acid/base properties of a molecule
Binding interactions
Q. 42 Donepezil is
a centrally acting reversible, non-competitive Acetylcholine esterase inhibitor
is an imidazoline α- antagonist
is a 5 HT1A antagonist
a selective α1-adrenergic blocker
Q. 43 During conjunction the genetic material will be transferred through
Cell wall
Medium
Pili
Capsule
Q. 44 Primary mediators in anaphylaxis
Histamine
Seratonin
Heparin
All of the above
Q. 45 Papain and opium can be grouped as
Dried juice
Dried latex
Resins
Dried extract
Q. 46 Which of the following auxin occurs naturally in plants ?
Indole acetic acid
Napthyl acetic acid
Indole butyric acid
Indole-3-acetonitrile
Q. 47 Leaf spot disease is due to
Ascochyta atropa
Cercospora atropa
Fusarium solanii
Phytophthora nicotiana
Q. 48 Alkaloidal extraction process was developed by
Ardy-Gallows
Stass-otto
Verma-Kaushik
Bentham-Hooker
Q. 49 Salicin is obtained from *
Stropanthus gratus
Strychnus nux-vomica
Withania somnifera
Salix sepulcralis
Q. 50 Astragalus gummifer is the main source of
Agar
Gelatin
Tragacanth
Starch
Q. 51 Melting point of coca butter is *
20 ºC
25 ºC
35 ºC
50 ºC
Q.52 Asafoetida obtained from the species of
Ferula
Styrax
Andrographis
Myroxylon
Q.53 Caffeine is identified by
Klung’s test
Millons test
Murexide test
Wagners test
Q.54 French chalk is the synonym of
Chalk
Talc
Fueller’s earth
Bentonite
Q.55 A high ratio of auxin to cytokinin in the culture medium induces
Shoots
Precipitation
Roots
Clumping
Q.56 The analytical constant of a bark is
Total ash value
Fibre length
Stomatal index
Iodine value
Q.57 The plant constituents having an astringent taste are
Volatile oil
Carbohydrates
Tannins
Alkaloids
Q.58 The drug possessing an acrid taste is
Gentian
Ginger
Linseed
Podophyllum
Q.59 A novel diterpenoid isolated from the bark of Taxus brevifolia
Demecolcine
Vinblastin
Brevifolicin
Paclitaxal
Q.60 Citrus flavonoids are rich in
Fraxin
Scopoletin
Hesperidin
Aesculetin
Q.61 WHO guidelines for the herbal drugs contaminants include
Amino acids
Pentoses
Pesticidal residues, arsenic heavy metals, microbial load
Purines and pyrimidine bases
Q.62 An essential ingredient in the general preparation of plant tissue culture media is
Auxin
Glucose or sucrose
Pyriddoxine HCl
Gibberlin G1/G2
Q.63 In Pharmacognosy, the crude drugs may be classified according to the following except
Alphabetically
Morphologically
Taxonomically
Geographical distribution
Q.64 Saponin containing drugs are used as
Laxative
Bitter tonic
Expectorant
Emetic
Q.65 Which of the following properties of a particle significantly affects the physical, chemical& biological properties of the drug ?
Density
Sedimentation
Size
Surface area
Q.66 When coulter-counter apparatus is employed for powder analysis , the following criterion is important
Dispersion medium should be coloured
Dispersion medium should be conducting
Suspended particles should be charged
Suspended particle should be spherical
Q.67 The type of particle diameter that is obtained by microscope method of evaluation is
Projected
Stokes
Volume
Volume-surface
Q.68 Parenteral drug products undergo what type of testing to ensure that all microorganisms have been destroyed or removed ?
Clarity testing
Pyrogen testing
Leaker testing
Sterility testing
Q.69 Pharmacopieal tests for ensuring the quality of drug products in tablet form include all of the following EXCEPT
Disintegration
Dissolution
Hardness & friability
Content uniformity
Q.70 When non polar substances dissolved in polar solvent using surfactants, the process is called *
HLB
Solubilization
Emulsification
Gelatination
Q.71 Tablets can be coated with various polymeric agents, which dosage form is formulated to dissolve in the intestine rather than the stomach ? *
Sublingual
Transdermal
Enteric-coated
Buccal
Q.72 A substance that is often used to sub coat tablet is *
Sugar
Carnauba wax
Shellac
Sodium stearate
Q.73 Rat-holing phenomena relates with
Poor flow of granules
Filling of capsules
Maintaining the flow of granules
Increase the flow of granules
Q.74 Z-value, a term used in sterilization, indicates
Temperature co-efficient of microbial destruction
Rate of microbial destruction
The number of microbes surviving in the loads
Time to increase to achieve 100% sterility
Q.75 Which compound is a natural emulsifying agent ?
Acacia
Lactose
Polysorbate-20
Sorbitan monopalmitate
Q.76 Rectal suppositories intended for adult use usually weigh approximately
1g
2g
3g
4g
Q.77 A satisfactory suppository base must meet all of the following EXCEPT
It should have narrow melting range
It should be nonirritating and nonsensitizing
It should be inert
It should melt below 30 °C
Q.78 Dose dumping is a problem in the formulation of
Compressed tablets
Modified-release drug products
Soft gelatin capsules
Suppositories
Q.79 What equation describes the rate of drug dissolution from tablets ?
Fick’s law
Noyes Whitney equation
Law of mass action
Michaelis-Menten equation
Q.80. The loading dose (DL) of a drug is usually based on the
Total body clearance(ClT) of the drug
Percentage of drug bound to plasma proteins
Apparent volume of distribution(VD) & desired drug concentration of plasma
Area under the plasma drug concentration versus time curve(AUC)
Q.81 The principle of superposition in designing multiple-dose regimens assumes that
Each dose affects the next subsequent dose, causing nonlinear elimination
Early doses of drug do not affect subsequent doses
The fraction of drug absorbed is equal to the fraction of drug eliminated
Each dose of drug eliminated by zero-order elimination
Q.82 A type of flow in which viscosity increases when the substance is agitated in
Plastic
Pseudoplastic
Dilatant
Thixotropic
Q.83 As per GMP permitted limit of solid content in water for injection is
100 ppm
1 ppm
10 ppm
0.1 ppm
Q.84 Which of the following radionuclides is most commonly used in nuclear pharmacy practice ?
67Ga
99mTc
133Xe
123I
Q.85 Example of a bioprecursor prodrug is
Cyclophosphamide
Pivampicillin
Progabide
Becampicillin
Q.86 Sedative action of C5 di substituted barbiturates is due to *
High lipophilicity of groups at C5 position
Electronic withdrawing effect
Steric effect
Metal chelation
Q.87 Immuno suppressants are also useful in the treatment of autoimmune diseases like
Meningitis
Osteoporosis
Myasthenia gravis
Dermatitis
Q.88 The three acidity constants of tetracyclines are *
pKa = 2.8 to 3.4, pKa = 7.2 to 7.8, pKa = 9.1 to 9.7
pKa = 5.8 to 6.4, pKa = 8.2 to 8.8, pKa = 10.1 to 10.7
pKa = 0.8 to 1.4, pKa = 3.2 to 3.8, pKa = 5.1 to 5.7
pKa = 4.8 to 5.4, pKa = 6.2 to 8.8, pKa = 11.1 to 11.7
Q.89 In the SAR of directly acting sympathomimetics optimal activity is seen only if the amino group is separated from the aromatic ring by
1-carbon
2-carbon
3-carbon
4-carbon
Q.90 When N – methyl group of morphine is replaced with an allyl group, the compound formed is
Naloxone – morphine antagonist
Naltrexone – morphine antagonist
Nalorphine – morphine antagonist
Nalbuphine – morphine agonist / antagonist
Q.91 The “Hemiacetal” form of aldosterone is between
C – 11, β – hydroxyl and C – 20 carbonyl
C – 11, β – hydroxyl and C – 21 hydroxyl
C – 11, β – hydroxyl and C – 18 carbonyl
C – 21, hydroxyl and C – 20 carbonyl
Q.92 Benzathine penicillin is *
an equimolecular composition of Amoxicillin + N, N dibenzyl ethylene diamine
a molecular complexation of Benzyl penicillin + N, N dibenzyl ethylene diamine
a molecular complexation of Cloxacillin + ethylene diamine
Q.93 Absolute stereochemistry of penicillin is designated as
3S:5R:6R
3R:5S:6S
3R:5R:6R
3S:5S:6R
Q.94 Biological activity of chloramphenicol is exclusively present in
Threo isomer
L-threo isomer
L-erythro isomer
D-erythro isomer
Q.95 Which of the following strategies will increase the polarity and water solubility of a drug ?
Removing polar functional groups
Adding extra alkyl groups
Replacing an aromatic ring with a nitrogen containing heterocyclic ring
Replacing an alkyl group with a larger alkyl group
Q.96 Which of the following major aims in drug design is not related to the pharmacodynamics of a drug ?
The reduction of side effects
The maximisation of activity
The reduction of toxicity
The maximisation of oral bioavailability
Q.97 GABA interaction with receptor results in
Influx of Cl–
Influx of Ca++
Influx of Na+
Influx of K+
Q.98 Which of the following is the general mechanism of action for erythromycin ?
Inhibition of a metabolic enzyme
Inhibition of cell wall synthesis
Disruption of protein synthesis
Inhibition of nucleic acid transcription and replication
Q.99 Which of the following is the general mechanism of action for fluoroquinolones ?
Inhibition of a metabolic enzyme
Inhibition of cell wall synthesis
Disruption of protein synthesis
Inhibition of nucleic acid transcription and replication
Q.100 Which of the following antidepressant drug is also a prodrug for an anti TB agent ?
Phenelzine
Tranylcypromine
Iproniazid
Imipramine